eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2026-03-30 23 1 1 16 10.13005/bbra/3476 58681 article Shaik Aminabee 1 Ogirala Umamaheswar Rao 2 Kunderu Ravi Shankar 3 Naga Venkata Chenchu Lakshmi Kollipara 4 Saritha Karnati 5 Atchutuni Venkata Subrahmanyeswara Ravi Sai Nadh 6 Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Andhra Pradesh, India. Head of Quality Assurance Unit, Vivo Bio Tech Limited, Hyderabad, Telangana, India. Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Andhra Pradesh, India. Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation (KLEF), Andhra Pradesh, India. Department of Pharmaceutical Chemistry, Dr. KV Subba Reddy College of Pharmaceutical Sciences, Kurnool, India. Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Andhra Pradesh, India. Smart nanobiotechnological platforms have become a solace of revolution in conquering the challenges linked to the traditional drug and gene delivery system. The platforms allow targeted, stimuli-responsive, and precise delivery of therapeutic agents by incorporating the benefits of nanotechnology, biotechnology, and pharmaceutical sciences. The biocompatibility, biodegradability and versatility of biopolymers have been vital in designing smart nanocarriers since the biopolymers can be used to efficiently encapsulate drugs and genetic materials and release them on demand. The given review will be a complete overview of the application of smart nanobiotechnological platforms in gene and drug delivery with a particular emphasis on the key principles of the design, nanocarrier biopolymers, and stimuli responsiveness. They are particularly stressed in relation to their use in gene therapy, cancer therapy, neurology, and infectious diseases. The review further talks of pharmacokinetic and pharmacodynamic factors, safety and toxicity issues, and regulatory issues that arise with nanobiomaterials. The latest developments, such as the AI-assisted nanocarrier design and individualized nanomedicine are also discussed. In general, this review highlights the promise of smart nanobiotechnological platforms, which can transform the concept of delivering therapeutic interventions and speed up the process of translating nanomedicine into clinical care. https://www.biotech-asia.org/vol23no1/smart-nanobiotechnological-platforms-for-gene-and-drug-delivery-from-biopolymers-to-pharmaceutical-applications/ Biopolymer-based nanocarriers; Gene delivery; Nanomedicine; Pharmaceutical applications; Smart nanobiotechnology; Stimuli-responsive systems; Targeted drug delivery