The search for effective antiviral agents against dengue virus (DENV) remains a global priority due to the absence of specific therapeutics. The present study evaluates selected phytochemicals from Carica papaya, Moringa oleifera, and Tinospora cordifolia using an in-silico molecular docking approach to identify compounds with potential dengue-related inhibitory activity. Phytochemicals were screened based on drug-likeness and ADME properties, and their disease-associated gene targets were identified through database mining. Venn analysis identified plasminogen (PLG), a host protein implicated in dengue-associated thrombocytopenia and vascular complications, as a common target linked to both dengue pathophysiology and the selected phytochemicals. The human plasminogen protein (PDB ID: 8UQ6) was selected for molecular docking using PyRx, and interaction analyses were performed with BIOVIA Discovery Studio. Among the evaluated compounds, carpaine from Carica papaya exhibited the highest binding affinity (−9.2 kcal/mol), followed by hesperetin from Moringa oleifera (−8.3 kcal/mol), whereas phytochemicals from Tinospora cordifolia showed comparatively lower affinities. These findings suggest that Carica papaya and Moringa oleifera contain phytochemicals capable of interacting with dengue-associated host molecular pathways. However, as molecular docking provides predictive insights only, these results are limited to in-silico observations and require further in vitro, in vivo, and clinical validation.