eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-12-30 22 4 1412 1429 10.13005/bbra/3451 57314 article Ameena Begum Abdul Rajak 1 Janani Senthil Kumaran 1 Monisha Senthamarai 1 Saravanan Kaliyaperumal 1 Department of Zoology, Nehru Memorial College (Autonomous), Tiruchirappalli, India. Arogyapacha (Trichopus zeylanicus Gaertn.) is an endemic medicinal herb of the Western Ghats. The Kani tribe worships it because of the amazing rejuvenating and adaptogenic effects and long-standing ethnomedicinal value. The review is a critical compilation of the existing evidence on the phytochemical composition and bioactive compounds by GC-MS of Trichopus zeylanicus. It has been shown in several studies that these compounds have a variety of biological activities thus scientifically explaining the traditional use of this endemic western ghats plant in medicinal practice. Its adaptogenic, hepatoprotective, antidiabetic, anti-ulcer, aphrodisiac, and cardioprotective properties are also supported by experimental research and are achieved by regulating the oxidative stress, inflammation, and endocrine balance. Toxicological analyses indicate that it is safe and can be used and incorporated in the polyherbal formulation Jeevani, which can be used as a model to share benefits fairly with indigenous communities. The pharmacological and ethnomedical potential of the plant highlights its importance in the development of formal pharmacopoeia and sustainable therapeutic development, where it is important to have integrative conservation measures to conserve such a valuable species of the Western Ghats. https://www.biotech-asia.org/vol22no4/traditional-uses-ethnobotanical-importance-and-modern-pharmacological-validation-of-trichopus-zeylanicus-an-indigenous-and-endemic-medicinal-herb-of-the-western-ghats/ Arogyapacha; Ethnopharmacology; Phytochemistry; Trichopus zeylanicus; Western Ghats