eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-12-30 22 4 1337 1348 10.13005/bbra/3445 56977 article Sonali Ravindra Patil 1 Santosh Subhash Chhajed 2 MET’s Institute Of Pharmacy, Bhujbal Knowledge City, Nashik, India. Department of Pharmaceutical Chemistry, MET’s Institute Of Pharmacy, Bhujbal Knowledge City, Nashik, India. Phytosomes are lipid based vesicular nanocarries that encapsulate phytoconstituents within phospholipid layers, designed to overcome the limitations of herbal extracts such as inadequate lipid solubility, restricted permeability, low bioavailability, and chemical instability, while improving the absorption, stability, and therapeutic efficacy of phytoconstituents or herbal extracts in pharmaceutical, nutraceutical, and cosmetic formulations. The review aims to provide an overview of phytosomes, including their complexation mechanism structural features, formulation methodologies, and characterization techniques for evaluation of this phyto-phospholipid complex. The review briefly summarizes phytosomes technology, including structural, molecular interaction between active agent and lipids, formulation techniques, storage conditions, stability considerations, and therapeutic applications, commercially available phytosome-based formulations, Challenges faced by technology emphasizing the role and importance of phytosomes as a promising platform for turning herbal active agents into effective and standardized dosage forms. https://www.biotech-asia.org/vol22no4/phytosomes-a-versatile-phyto-phospholipid-nanocarriers-a-review/ Absorption; Bioavailability; Encapsulation; Nanocarriers; Phytosomes; Phospholipid