eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-12-30 22 4 1349 1355 10.13005/bbra/3446 56756 article Sura Maan Salim 1 Department of Pharmacognosy, College of pharmacy, University of Mosul, Iraq. A commonly utilized beta-hydroxy acid, salicylic acid is essential in dermatology, especially for treating acne. Its medicinal and pharmacological characteristics, methods of action, and efficacy in controlling certain skin disorders are investigated in this article. Salicylic acid is quite powerful against inflammatory and non-inflammatory acne as it acts as a keratolytic and comedolytic agent, stimulates exfoliation, and lowers sebum production, as a result, clearing blocked pores. Its anti-inflammatory and antibacterial properties are also investigated in this article, thereby stressing its capacity to control Cutibacterium acnes spread and lower inflammation. Along with its ideal concentrations and treatment times, salicylic acid's practical uses—including its inclusion into cleansers, peels, and gels—are examined. The outcome underlines the therapeutic relevance of salicylic acid as a safe, efficient, flexible topical therapy providing significant advantages with minimum adverse effects for different skin types. https://www.biotech-asia.org/vol22no4/emerging-formulations-and-clinical-applications-of-topical-salicylic-acid-in-acne-management/ Acne; Anti-inflammatory; Exfoliation; Salicylic acid; Skincare