eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-12-30 22 4 1494 1511 10.13005/bbra/3456 57281 article Krishna Bhagwan Bharti 1 Pranoti Sunil Mohod 1 Raksha Laxman Mhetre 1 Shashikant Nivrutti Dhole 1 Nilesh Shrikant Kulkarni 1 Department of Pharmaceutical, Affiliated to Savitribai Phule Pune University, Modern College of Pharmacy, Pune, India. Both natural and synthetic polymers are crucial for dosage forms and packaging materials in the pharmaceutical industry. The use of biodegradable polymers in drug delivery systems has increased recently, and their ease of excretion from the body makes them particularly desirable. The potential for controlled drug release in biomedical applications has been shown by the effective loading and release of a range of pharmaceuticals utilizing polylactic acid (PLA) based polymers, highlighting the need for modification to accept both hydrophobic and hydrophilic medications. PLA is also utilized as a tissue anti-adhesion substance and as a product packaging material. This review covers the manufacture and modification of (PLA) for a range of biomedical uses, such as nanoparticles, copolymers, injectable hydrogels, microspheres, nanofibers, transdermal, liposomes, microfibers, sol gels drug delivery systems and tissue engineering. It investigates surface modification methods such coating, chemical modification, and plasma treatment as well as the copolymerization of lactide with other monomers like malic acid, PEG, and PGA. The FDA has approved PLA-based polymers, such as PLGA, for use in prolonged medication release formulations and bioresorbable sutures. The creation of injectable hydrogels made of sulfobetaine-modified PLA for anti-adhesion and hemostasis, as well as PLA nanoparticles loaded with curcumin for tissue engineering and controlled drug release, are also covered in the paper. Mannan-decorated PLGA nanoparticles for cancer immunotherapy are also investigated; in mouse models, they show improved immune responses and tumor regression. these developments hold great promise for tissue engineering and medical treatments. https://www.biotech-asia.org/vol22no4/a-comprehensive-review-on-applications-of-polylactic-acid-in-novel-drug-delivery-system/ Applications; Biodegradable polymers; Nanoparticles; Novel drug delivery system; Polylactic acid; Tissue engineering