eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-12-30 22 4 1398 1411 10.13005/bbra/3450 56926 article Vaishnavi Kadali 1 Prashant Unde 2 Laxmikant Borse 3 Department of Pharmaceutical Quality Assurance, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra Department of Pharmaceutical Chemistry, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra In today’s pharmaceutical world, where advanced instruments like NIR, FTIR, Raman, and HPLC generate huge volumes of complex data, chemometrics has become an essential tool. It combines statistics, mathematics, and computer science to help scientists understand and make use of this data in smarter ways. This review highlights how chemometric techniques are being used to improve pharmaceutical analysis, from raw materials to final products. These tools help overcome challenges in traditional methods, such as overlapping spectra or detecting ingredients present in very low concentrations. Chemometrics is also making routine tasks like calibration curve generation, impurity profiling, and dissolution studies faster, more accurate, and less dependent on complex separations. It supports techniques like UV-Vis, NIR, and NMR spectroscopy, and even helps with optimizing eco-friendly methods in line with green chemistry goals. Overall, chemometrics bridges the gap between complex analytical data and practical decision-making. It’s not just about crunching numbers- it’s about empowering researchers to ensure the safety, quality, and effectiveness of medicines with greater confidence and efficiency. https://www.biotech-asia.org/vol22no4/a-comprehensive-review-of-advancing-pharmaceutical-analysis-technology-through-chemometrics-approaches/ Chemometrics; Multivariate analysis; Pharmaceutical analysis; Process analytical techniques (PCA); Spectroscopy (FTIR NMR UV-Vis)