eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-09-30 22 3 1235 1242 10.13005/bbra/3436 56015 article Mebin John Bosco 1 Dheepan George 1 Department of Microbiology, AVS College of arts and science (Autonomous), Salem, India. The goal of the quest for an efficient Aspergillus oryzae bioimmunostimulant was to improve soil fertility and control illnesses in paddy farming. Aspergillus oryzae strains were selected and assessed for their capacity to generate bioactive substances with immunostimulant control in paddy farming using a methodical process. The effectiveness of the bioimmunostimulant in increasing soil fertility and preventing illnesses in rice fields was validated by bioactivity tests. According to the study, bioimmunostimulants promote the growth of beneficial microbial populations, trigger defence mechanisms in plants, and enhance the uptake and use of nutrients, venting illnesses in rice fields was validated using bioactivity tests. Field tests indicated improvements in crop health, nutrient availability, and soil microbial activity while reducing the incidence and severity of paddy diseases. https://www.biotech-asia.org/vol22no3/a-comprehensive-study-of-aspergillus-oryzae-derived-bioimmunostimulants-for-enhancing-soil-fertility-and-managing-diseases-in-oryza-satival/ Aspergillus oryzae; Bioactive compounds; Bioimmunostimulant; Crop health; Defense mechanisms; Soil fertility