eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-06-25 22 2 459 467 10.13005/bbra/3376 55331 article Gayathri Sivakumar 1 Sivasubramani Kandasamy 1 Department of Microbiology, Faculty of Science, Annamalai University, Chidambaram, Tamil Nadu, India. Cosmetics, integral to personal care, have faced scrutiny due to the potential health hazards posed by synthetic ingredients. This review explores the diverse applications of seaweed-derived bioactive compounds in cosmetic science, presenting a comprehensive examination of their impact on skin health. The rising concerns about the adverse effects of synthetic cosmetics, including carcinogenic properties, have propelled the search for natural and sustainable alternatives. Seaweeds, as macroscopic algae, offer a rich source of bioactive molecules such as fucoidans, alginates, carrageenans, mycosporine-like amino acids (MAA), and more. These compounds exhibit multifaceted functionalities, including antioxidant, anti-inflammatory, anti-aging, antimicrobial, UV protection, and skin-whitening effects. The review delves into extraction methods, processing techniques, and formulation strategies, emphasizing the potential of nanosystems to enhance stability and efficacy. Challenges, including heavy metal accumulation, are discussed, underscoring the importance of rigorous chemical analysis for safety in cosmetic applications. The review concludes by highlighting future directions, including optimizing extraction processes, increasing bioactive molecule production, and conducting more clinical studies to ensure product safety and quality. In essence, seaweed-derived bioactive compounds present a promising avenue for the development of natural and effective cosmetic formulations with diverse skincare benefits. https://www.biotech-asia.org/vol22no2/seaweed-derived-bioactives-in-cosmetics-a-detailed-review-on-skin-health-benefits/ Anti-Aging; Anti-Inflammatory; Bio-actives; Cosmetic Science; Seaweed; Skincare