eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2025-06-25 22 2 521 534 10.13005/bbra/3380 55457 article Gauravi Sunilrao Kherde 1 Rahul Dnyaneshwar Khaire 2 Vikas Dhamu Kunde 1 Pooja Gajanan Akoshkar 1 Pratiksha Suresh katkade 1 Komal Sunil Taru 1 Department of Pharmaceutics, PRES’s College of Pharmacy (For Women), Chincholi Tal-Sinnar, Dist-Nashik , India Department Of Quality Assurance, PRES’s College Of Pharmacy (For Women), Chincholi Tal-Sinnar, Dist-Nashik , India The perfect properties of mesoporous silica nanoparticles (MSNs), such as their wide surface area, large pore size, and biocompatibility, have attracted good consumers for topical medicinal goods in recent years. This systematic review focus to impart an in-depth outline of recent developments in MSN-based cosmetics and highlight their potential in dermatological and cosmetic applications. mesoporous silica nanoparticles provide a multiple platform for the encapsulation and prolonged release of numerous medical compounds, including anti-inflammatory and developmental drugs, thereby improving the therapy of numerous skin diseases like acne, psoriasis, and wounds. In addition, MSN are increasingly used to deliver antiaging and skin rejuvenating active ingredients, promote skin penetration, and enhance stability. This review also explores the challenges and strategies to optimize mesoporous silica nanoparticles structures to improve skin permeability, long-term drug release, and delivery. This article summarizes recent developments, highlighting a increasing potential of mesoporous silica nanoparticles based cosmetic techniques to improve clinical outcomes and attention to detail in dermatology, while also addressing future directions and research gaps in this field. https://www.biotech-asia.org/vol22no2/recent-advances-in-mesoporous-silica-nanoparticle-based-topical-delivery-systems-a-systematic-review/ KIT-5; Mesoporous silica nanoparticles; MCM-41; SBA-16; MCM-50