eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2024-07-01 21 2 723 730 10.13005/bbra/3259 51663 article Nagalakshmi CS 1 Shaheen Shaikh 2 Rajeev Gandham 3 Santhosh NU 4 Department of Biochemistry, Chikkaballapura Institute of Medical Sciences, Chikkaballapura, Karnataka, India. Department of Biochemistry, Yenapoya Medical College, Deralakatte, Mangalore, Karnataka, India. Department of Biochemistry, NRI Institute of Medical Sciences, Visakhapatnam, India. 4Consultant Neurosurgeon (Endovascular Neurosurgeon), Aster CMI Hospital, Hebbal, Bengaluru, Karnataka, India. Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2), primarily acts on lungs. Most of these patients present with typical respiratory symptoms and signs. SARS-CoV-2, mainly detected by nasopharyngeal/oropharyngeal swab(s) of suspected subjects. The present study aimed at evaluating and discussing the alterations in biochemical and hematological parameters in COVID-19 patients in a tertiary care hospital. This observational study was conducted in a Tertiary care hospital, Coastal Karnataka, India. In this study, 124 COVID-19 patients were involved. Co-morbidities, such as hypertension was observed in 98 (79%), diabetes in 91 (73.3%), cardiovascular disease in 20 (16.1%), chronic kidney disease in 4 (3.2%) and liver disease in 2 (1.6%) cases. Hypertension and diabetes were more common. Symptoms such as fever was found in 109 cases (87.9%), dry cough in 102 (82.2%), fatigue in 89 (71.7%), chest tightness in 79 (63.7%), myalgia in 67 (54%) and mild shortness of breath in 46 (37%) cases. In this study, hemoglobin (9.4±1.7 %) and platelets (240.1±89.7) were decreased and erythrocyte sedimentation rate (ESR) (50.7±15.7) significantly increased in severe cases. Mean values of random blood sugar (RBS) was 245.6 ± 126.9 mg/dl, HbA1c 7.9±2.8%, serum urea 82.8±25.2 mg/dl, Creatinine 3.2±1.5 mg/dl, Uric acid 6.8±1.5 mg/dl), Total Bilirubin 1.2±0.6 mg/dl, Alkaline Phosphatase 135.4±38.9 IU/L, C-Reactive protein (CRP) 84.8±7.7 mg/L, lactate dehydrogenase (LDH) 644.6±175.1 U/L, Ferritin 828.3±195.4 µg/L, D-Dimer [2680.9 (1899.0-5475.7 ng/ml)] were elevated in severe cases than mild group. In contrast, serum total proteins (6.3±0.7g%) and globulin (2.8±0.5 g%) levels were significantly decreased in severe cases than mild/moderate cases. Study may conclude that presence of co-morbidities, abnormalities in biochemical and hematological parameters, should be regularly monitored, especially in severe / critical COVID-19 patients. https://www.biotech-asia.org/vol21no2/the-spectrum-of-biochemical-and-haematological-alterations-in-covid-19-patients-attending-a-tertiary-care-hospital-in-karnataka-india/ biochemical; Covid-19; D-dimer; Ferritin; hematological parameters; Liver function tests; renal function tests