eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2024-07-01 21 2 537 545 10.13005/bbra/3245 51891 article Riya Gajendranath Upadhyay 1 Pradeep Kumar Singh 1 Department of Life Science, Rai School of Sciences, Rai University, Ahmedabad, Gujarat, India. Drug are used to treat the infection as antibiotics a low molecular weight molecule used to treat different bacterial infections. But the increasing drug resistance put danger to global healthcare and the treatment efficacy worsening the healthcare outcomes. Multidrug Resistance (MDR) by biofilm making the infection control complex. There are few prevention measures of this drug resistance but the use of technology with combination of the omics field may be used to develop the natural products faster than the already existing methods. This review focuses the golden era of antibiotics and how this era got shadow of resistance and strategy to overcome this. Also, the mechanism and future strategies which can be used to fight against this resistance threat is spotlighted. The use of technology collaboration and surveillance aspects are briefly explained. https://www.biotech-asia.org/vol21no2/strategies-to-combat-drug-resistance-innovations-and-challenges-a-review/ Antibiotics; Drug resistance; Mechanism of resistance Collaboration; Multi-drug resistance; Omics; Surveillance