eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2023-09-30 20 3 793 816 10.13005/bbra/3132 47133 article Shubham J. Khairnar 2 Ghanshyam B. Jadhav 1 Department of Pharmacology, NDMVP Samaj’s College of Pharmacy, Nashik, India Department of Pharmacology, MET’s Institute of Pharmacy, Adgaon, Nashik, India A central or peripheral somatosensory nervous system lesion or illness is a common cause of neuropathic pain. In this study, we address the most recent information on neuropathy, as well as the causes, symptoms, and treatments of neurodegenerative illnesses like Alzheimer's, Parkinson's, Huntington's, and Amyotrophic Lateral Sclerosis. While, in recent years, phenolic acid supplementation has been associated to enhanced cognitive function and the prevention of cognitive deterioration. The pharmacological effects of phenolic acid are discussed in this review. And gives the overview of role of Reactive oxygen Species (ROS), oxidative stress and antioxidants in neuropathy, and stated the strong relation between stress, tension, hectic lifestyle and neurodegenerative diseases. https://www.biotech-asia.org/vol20no3/neuroprotective-action-of-polyphenols-and-phenolic-compounds-an-overview/ Free Radicals; Neuroprotective; Neuropathic pain; Neuropathy; Polyphenols; Phenolic Compounds; Reactive Oxygen Species