eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2023-06-30 20 2 537 545 10.13005/bbra/3108 45866 article Sourabh Sharma 1 Rahul Gupta 2 Jyotdeep Kour Raina 3 Ravi Sharma 4 Parvinder Kumar 4 Rakesh Kumar Panjaliya 4 Department of Zoology, University of Jammu, J and K, India, 180006 Department of Urology, Govt. Super Speciality Hospital, Jammu, India, 180016 GGM Science College, Jammu, India, 180001 Department of Zoology, University of Jammu, J and K, India, 180006 The rising incidence rates of prostate cancer (CAP) have become a global health disorder. Its complex aetiology includes potentially modifiable environmental factors and non-modifiable genetic components. In this study, we aimed to identify the potential and significant non-genetic risk factors associated with CAP in the population of Jammu and Kashmir. A total of 320 study subjects (120 clinically confirmed CAP patients and 200 healthy age-matched unrelated participants) were registered for this investigation after obtaining their prior consent. A predesigned health questionnaire and hospital-based patient history were used to collect data about clinical variables, sociodemographic characteristics, anthropometric parameters, and biochemical indices. The result revealed that dietary patterns (non-vegetarianism, p=0.01), lack of physical activity (p=0.0007), dwelling (urban residents, p=0.0105), higher levels of serum LDL-cholesterol (p=<0.0001),  triglyceride (p=0.01),  VLDL-cholesterol (p=0.02), total cholesterol (p=0.0527), creatinine (p=0.0006), sodium (p=0.0429), urea (p=0.0006), and PSA (p=<0.0001) were significantly associated with CAP. Moreover, higher mean age (69.82±15.5), the extent/duration of diabetes mellitus (DM) (p=0.0007), lack of physical activity (p=0.0007), high intake of red meat (p=0.0005), LDL-Cholesterol (p=<0.0001) and positive family history (p=<0.0001) were found to be the most significant risk factors for CAP. The study notably identified the novel (extent/duration of diabetes and serum levels of LDL, VLDL) non-genetic risk factors associated with prostate cancer in the population of the Jammu region of J&K. https://www.biotech-asia.org/vol20no2/association-of-non-genetic-risk-factors-with-prostate-cancer-in-the-population-of-jammu-region-of-j-and-k-india/ Cases; Controls; Clinical Variables; Prostate cancer (CAP); Risk Factors