eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2023-03-30 20 1 127 134 10.13005/bbra/3075 44299 article S.Imam Pasha 1 Aliya Meraj 1 Arshiya Meraj 1 Arwa Mohammed 1 Akifa Tanzil 1 Anam Fatima 1 Sultan-ul-Uloom College of Pharmacy, Banjara hills, Hyderabad-500034, Telangana, India. This article describe the preparation of valerianic acid loaded HPMC nanoparticles (NPs) using the nano-precipitation method. Objective of this study include enhancement of the dissolution rate of the poorly water soluble drug(Valerenic acid obtained from Valerianawallichii), and further more to look into the in vitro properties, zeta potential and surface characteristics of nanoparticles (percent yield of nanoparticles, percent encapsulation efficiency and in vitro release characteristics).In phosphate buffer medium at pH 6.8, the cumulative drug release from the original drug and nanoparticles were up to about 12% and 35%, respectively. Valerianic acid release can be enhanced by the use of nanoparticles loaded with hydroxy propyl methyl cellulose (HPMC), that also enhances bioavailability and patient compliance. https://www.biotech-asia.org/vol20no1/preparation-and-in-vitro-haracterization-of-valerianic-acid-loaded-polymeric-nanoparticles/ HPMC; In vitro release; Nanoparticles; Valerianawallichii; Valerianajatamansi