eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-01-05 1 1 53 56 3376 article H. S. Patel 1 H. J. Mistry 1 H. D. Desai 1 Department of Chemistry, S. P. University, Vallabh Vidyanagar - 388 120, Gujarat (India) 4-(4’-sulphanilyl)-1-methyl piperazine (2) has been prepared by the reaction of N-acetyl sulphanilyl chloride (ASC) with 1-methyl piperazine followed by the hydrolysis of the product with ethanolic HCl. This compound (2) under go condensation with aromatic aldehydes to give the corresponding Schiff’s base (3a-h). The Schiff’s base (3a-h) on cyclocondensation reaction with thioglycolic acid gives 4-thiazolidinones. Biological screening of the prepared compounds has been carried out on some strains of bacteria. https://www.biotech-asia.org/vol1no1/synthesis-and-antimicrobial-activity-of-some-new-thiazolidinones-containing-n-methyl-piperazine/ Schiffs base; thiazolidinones; antimicrobial activity