The Ganges is home to a high variety of microorganisms, both beneficial and harmful. Anthropogenic activities cause depletion in microbial communities at urban sites of river Ganga. From the ancient period, it is believed that purification of Ganges Water does not possible after long storage and so it can be used frequently for cooking, drinking, or bathing purposes. About 200 years ago, British colonial scientists suggested that Ganga may contain unique microbial life, which makes it relatively more resilient to putrefaction. That unique microbial life is the virome. The presence of various kinds of viruses gives Ganga its self-purificatory property.