The COVID-19 had been emerged as a pandemic and resulted in more than 273 million reported cases and 5.3 million deaths worldwide. Concerns have been raised regarding this virus due to its unprecedented ability to move from human to human and cause infections, acute morbidity, and fatal outcome. Gut and lung microbiome profile substantially depends on dietary habits and plays a major role in modulating immunity thereby providing resistance to viral infections. The Gut-lung axis shows a correlation in microbial profile and the gastrointestinal microbiota can modulate lung microbiota majorly through the impact of microbial metabolites. Firmicutes and Actinobacteria specifically Bifidobacterium and Lactobacillus are responsible to modulate immunity and are widely used as probiotic species. In this review, we have concluded that different dietary habits affect microbial diversity and it can be a determining factor to fight SARS-CoV2 infections.