eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2021-10-27 18 3 575 583 10.13005/bbra/2941 39371 article Esmat Laiq 1 Nida Shahid 2 Chemistry Section, Women’s College, Department of chemistry, Aligarh Muslim University, Aligarh, India– 202002 Department of chemistry, Arya Mahilla (P.G.) College, Shahjahanpur, India,-242001 The correlative antimicrobial analysis of amino acid Schiff base and derivatized tren metal complexes: A= [MLCl₂], B= [ML(CH₃OH)₂], respectively, against fungal strains, Candida parapsilosis, Candida albicans, Candida krusei, and Cryptococcus neoformans and (Gram-negative) P. aeruginosa,  E. coli, S. typhimurium, and S. pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans (Gram-positive) bacterial strains had been done by disk diffusion method following McFarland protocol. [CuLCl₂] and [Cu (CH₃OH)₂] manifest overwhelming activity against microbes than other metal complexes of cobalt, nickel and zinc. Minimum inhibition concentration data also shows that copper complexes have the lowest MIC values against these tested microorganisms. The significance of this investigation is to uncover shielding and constructive therapeutic agents that wield against bacterial and fungal infection. https://www.biotech-asia.org/vol18no3/antimicrobial-activities-of-schiff-base-metal-complexes-of-first-transition-series/ Antibacterial; Disk Diffusion Method; Minimum Inhibitory Concentration (MIC); l-leucine; Schiff base; Thiophene 2-carboxaldehyde