eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2020-06-25 17 2 413 419 10.13005/bbra/2845 36158 article Rehab S. Ramadhan 1 Al- Esraa University College, Baghdad, Iraq Samples of 500 patients suffering from Sickle Cell Disease (SCD) were collected from Ibn Al-Baladi hospital and subjected for blood analysis. Most patients showed an elevated level of HbF, HbA2, iron and eosinophels. Two primers were designed to amplify two regions of β-globin gene, the first targeting the site from which gene expression begins, and the other is targeting the coding region Dgn83. Results showed the presence of a common pathogenic mutation of Arab countries at HBB, LOC107133510, LOC110006319 with phenotype MIM 603903, while changes were detected at Dgn83 with not attribution to SCD. It is concluded that such mutation is the main cause of SCD in Arab countries with specific phenotype that differ from other countries around the world. https://www.biotech-asia.org/vol17no2/prognosis-of-an-inherited-beta-globin-deficiency-in-sickle-cell-anemic-iraqi-population/ Blood Disorder; Beta Globin; Mutation; SCD