eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2020-06-25 17 2 319 327 10.13005/bbra/2835 35752 article Al- Otaibi, Wafa Mohammed 1 Jazem A. Mahyoub 2 Khalid Mohammed Alghamdi 2 Department of Biology, Taif University, Taif, KSA. Department of Biology, Abdul-Aziz University, Jeddah, KSA. The red palm weevil, Rhynchophorus ferrugineus (Olivier) (Coleoptera: Dryophthoridae) is one of the most threatening pests for date palm trees in Kingdom of Saudi Arabia. It is considered  as an  insect pest  from category I in the Gulf region and the Middle East, according to the Food and Agriculture Organization (FAO). The difficulty of controlling the weevil chemically is due to its hidden life habits inside the trunk of palm. The excessive use of large quantities of insecticides made it possess resistance against many of them. Therefore, it was important to carry out this research to investigate the level of sensitivity of weevil larvae against some common insecticides as used in Makkah AL Mukarramah region. The effectiveness of three pesticides was tested (Fiprol: cyclodines ;Imidaprid: neonicotinoid and Dueracide: organophosphate) through feeding and dipping techniques. The results revealed that Fiprol was the most effective against R. ferrugineus larvae where LC₅₀ was (0.896-71.2 ppm) by feeding and dipping methods respectively. Then, Dueracide and Imidaprid were tested with LC₅₀of (54.2 -115.9 ppm), respectively. The LC₅₀ of Imidaprid  by dipping method showed (112.5 ppm) while the Dueracide was foundthe least effective by dipping treatment  where the LC₅₀ was (1003.8 ppm). According to the values of resistance ratio(RR),Fiprol was more effective than Dueracide and Imidaprid by (60.53 - 129.37) times respectively, by feeding method and  about (1.57 and 14.68 ) times respectively, compared to Imidaprid and Dueracide by dipping. Generally, treatment by feeding was (59.58) times more effective than by dipping. https://www.biotech-asia.org/vol17no2/evaluation-of-fiprol-imidaprid-and-dueracide-insecticides-against-larval-stage-of-red-palm-weevil-rhynchophorus-ferrugineus-olivier-in-makkah-al-mukarramah-region/ Control; Cyclodines; Makkah Al Mukarramah Region; Neonicotinoid ; Organophosphorus; Rhynchophorus Ferrugineus.