eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2020-03-30 17 1 115 126 10.13005/bbra/2816 35431 article Parvin Zeenath Anwar 1 Uma Gowrie Sezhian 1 Arunagirinathan Narasingam 2 Department of Plant Biology and Plant Biotechnology, Ethiraj College for Women (Autonomous), Chennai,Tamil Nadu, India, 600008 Department of Microbiology and Biotechnology, Presidency College, Chennai, Tamil Nadu, India, 600005 The medicinal plant Cissus quadrangularis has been extensively explored with respect to the presence of phytochemicals and their bioactivities. The available research data on endophytic bacteria of this plant is very limited. The main objective of this study is to isolate endophytic bacteria from the stem of Cissus quadrangularis and to determine the presence of bioactive compounds, antioxidant and antiosteosarcoma potential of the extracellular ethyl acetate crude extracts of endophytic bacteria.  One of the isolates CqB14 was identified to be similar to Pseudomonas sp. as analyzed by 16S rRNA sequencing. Qualitative phytochemical screening and HPTLC analysis of the extracellular ethyl acetate crude extract of CqB14 showed the presence of alkaloids in addition to other secondary metabolites. GCMS analysis predicted the presence of antimicrobial and anticancerous compounds. This study also reveals the antioxidant and antiosteosarcoma potential of endophytic bacteria from Cissus quadrangularis. https://www.biotech-asia.org/vol17no1/endophytic-bacteria-from-cissus-quadrangularis-a-promising-source-of-bioactive-compounds/ Antiosteosarcoma; Antioxidant; Cissus Quadrangularis; Endophytic Bacteria; GCMS Analysis; HPTLC