eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2018-09-25 15 3 577 589 10.13005/bbra/2664 31152 article Shakir Ullah 1 Gul Jan 1 Farzana Gul Jan 1 Siraj Khan 2 Maria Khattak 2 Hamida Bibi 3 Department of Botany Garden Campus, Abdul Wali Khan University, Mardan, Pakistan. Department of Botany, Hameeda bibi Hazara University, Mansehra, Pakistan. In the present research work the phytochemical investigation of methanolic, ethanolic and chloroform extracts of Cyrtomium caryotideum, Anti-pyretic and antifungal activities in methanolic, ethanolic and chloroform extracts  was carried out. The phytochemicals analysis showing the presence of carbohydrates, flavonoids, phlobatannins, alkaloids, saponins, tannins, phenols, terpenoids, cardiac glycosides was present in methanolic and ethanolic extracts, while alkaloids, phlobatannins, glycosides and protein were absent and quantative phytochemistry showed the flavonoids in chloroform extract as (14.20±0.15mg/ml), Alkaloids (12.10±0.15mg/ml), phenolics (10.45± 0.10mg/ml), Saponins (06.22±0.14mg/ml) and Tannins (04.60±0.65 mg/ml). The pharmacological activities such as, Anti-pyretic was carried out by brewer yeast induced pyrexia. The dose of 600 mg/kg of extract showed remarkable anti-pyretic activity (59.43%) when compared with positive control paracetamol (37.24oC) inhibition (73.23%).In antifungal activity the most active among the extracts was with (17.00±0.48 mm) zone of inhibition at the concentration of18 mg/µl against Verticellium. Fallowed by Pythium (16.27±0.93mm), Acremonium (16.20±1.89mm) and Trichoderma (16.11± 0.82) with concentration of 12 mg/µl. https://www.biotech-asia.org/vol15no3/phytochemical-analysis-antipyretic-and-antifungal-activities-of-cyrtomium-caryotideum/ Antipyretic; Antifungal Activities; Cyrtomium Caryotideum; Khyber Pakhtoon Khwa Pakistan; Phytochemical Analysis