eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2018-09-25 15 3 679 685 10.13005/bbra/2676 31040 article Ranjith Ramanujam 1 Balraj Sundaram 1 Ganesh Janarthanan 1 Elamparithi Devendran 2 Moorthy Venkadasalam 2 M.C. John Milton 1 Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India. Department of Biotechnology, Annai College of Arts and Science, Kumbakonam, Tamil Nadu, India. Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications. https://www.biotech-asia.org/vol15no3/biodegradable-polycaprolactone-nanoparticles-based-drug-delivery-systems-a-short-review/ Controlled Drug Release; Drug Delivery; Nanoprecipitation; Polycaprolactone Nanoparticles