eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2018-03-25 15 1 71 77 10.13005/bbra/2609 29303 article Nagapuri Kiran Kumar 1 Mesram Nageshwar 1 Karnati Pratap Reddy 1 Department of Zoology, Osmania University, Hyderabad, Telangana, India. This study reports the ameliorative role of curcumin against sodium fluoride (NaF) induced oxidative stress in the brain of rats. The rats were divided into control, NaF (20 mg/kg), NaF+Curcumin (20mg/kg) and Curcumin (20mg/kg) groups respectively and treated at everyday interval for 60 consecutive days. Oxidative stress markers in the brain were measured at 60^th day. NaF treatment significantly increased LPO content, but decreased the level of GSH and activities of SOD, GPx, and CAT the brain of rats in comparison to the control rats. Oral administration of curcumin to fluoride exposed rats significantly reversed the content of lipid peroxidation, as well as enhanced the level of GSH and SOD, GPx and CAT activities to normal compared to NaF exposed rats. Thus, curcumin showed the potential to prevent sodium fluoride induced oxidative damage in the brain of rats and curcumin may be useful agents against neurodegeneration in the brain. https://www.biotech-asia.org/vol15no1/curcumin-reduce-sodium-fluoride-induced-oxidative-stress-in-rat-brain/ Curcumin; NaF; Neurodegeneration LPO;Oxidative Stress;