eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2017-12-25 14 4 1355 1362 10.13005/bbra/2580 28201 article Balraj Sundaram 1 M. C. John Milton 1 P. G. and Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India. A biodegradable three-dimensional scaffolds have gathered attention and are widely studied for bone tissue engineering applications. In the present study, porous polycaprolactone scaffold entrapped with naringin loaded bovine serum albumin nanoparticles (PS-N-BSANP) has been engineered. Further, the prepared nanoparticles and interconnected porous scaffolds were characterized by scanning electron microscopy, X-ray diffraction and fourier transform infrared spectroscopy analysis. X- ray diffraction showed amorphization of naringin in PS-N-BSANP. In addition, sustained naringin release profile was observed from PS-N-BSANP for 12 days which showed a cumulative release of 52.54 micromolar (µM). Furthermore, conditioned medium from PS-N-BSANP showed an increased calcium deposition and collagen matrix formation under osteogenic conditions with C3H10T1/2 cell line. These results suggest that PS-N-BSANP enhanced the osteogenic differentiation potential in bone tissue engineering applications due to the controlled release of naringin. https://www.biotech-asia.org/vol14no4/porous-polycaprolactone-scaffold-engineered-with-naringin-loaded-bovine-serum-albumin-nanoparticles-for-bone-tissue-engineering/ Bovine Serum Albumin Nanoparticles;Bone Tissue Engineering; C3H10T1/2 cell line Naringin; Polycaprolactone Porous Scaffold;