eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2017-09-25 14 3 1117 1120 10.13005/bbra/2549 26889 article Sumithra M. 1 Chitra V. 1 Srm College of Pharmacy, Srm University, Kattangulathur. The stimulation or suppression of the immune response may modulate disease free state. Herbal medicine paved way for immunmodulation role in many mmunological disorder. The present study was  aimed to prove the traditional claim on the theimmunomodulatory activity ofAvicenniaofficinalisagainst autoimmune diseases. TheAvicenniaofficinalis leaves was authentified and coarsely powdered then extracted successively with  n-hexane,70% hydroalcohol followed by, ethylacetate. The phytoconstituentsofthe three extracts  were analysed . Finally, all were  subjected to (NBT) Nitrobluetetrazolium Assay, Candidacidal assay and Phagocytotic evaluation. The percentage yield and phytoconstituents of the extracts were determined. Among thethree extract, the ethanolic extract and Ethylacetateextractshowed effective immunomodulatory effect by their  suppression of leucocytes and neutrophils. The results of the present study proved the immunomodulatory effect of Avicenniaofficinalis and further studies  are essential to target this species against autoimmune diseases. https://www.biotech-asia.org/vol14no3/in-vitro-immunomodulatory-effect-of-hydroalcoholic-leaves-extract-of-avicennia-officinalis/ Candidacidal assay; Immunomodulation; Nitrobluetetrazolium Assay; Phagocytosis