eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2017-06-28 14 2 853 856 10.13005/bbra/2518 25939 article Vedamanickam R. 1 Vinoth Kumar 2 Nagendran Dinakaran 3 Department of Medicine, Sree Balaji Medical College and Hospital, Chrompet, Chennai – 600044. MGE, Sree Balaji Medical College and Hospital, Chrompet, Chennai – 600044. Senior Consultant Gastro Enterologist. Gastroesophageal reflux disease (GERD) represents a wide spectrum of clinical symptoms. Apart from reflux damage of oescophageal mucosa, it reflects sense of ill feeling and quality of life both physically and psychologically. The key factor in the pathogenesis is exposure of the gastric acid into the oesophageal mucosa in GERD. Various therapeutic modalities are available for the treatment of GERD among which proton pump inhibitors (PPI) hold the key. As a class these drugs are extremely safe and efficient in short term therapy. But reports on its long term efficacy are very few in Indian literature. This study stresses the long term efficacy of PPIs in GERD. https://www.biotech-asia.org/vol14no2/comparative-clinical-trial-on-the-efficacy-and-tolerability-of-esomeprazole-versus-rabeprazole-in-gastro-esophageal-reflux-disease-a-long-term-study/ Gastroesophageal; pathogenesis; modalities