eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2017-03-25 14 1 357 365 10.13005/bbra/2453 23070 article S. Gopalakrishnan 1 T. Ramakrishnan 2 P. Harinath 3 Joyson Moses 4 V. Shankarram 5 Samuel Raj 6 Department of Periodontics,Thai Moogambigai Dental College and hospital, Chennai -600107. Department of Periodontics, Aadhiparasakthi Dental College Chennai. Department of Periodontics,SRM Dental College and Hospitals,Ramapuram, Chennai. Department of Pedodontics, Thai Moogambigai Dental College and hospital, Chennai- 600107. Department of Periodontics Thai moogambigai dental college Chennai. Department of public health dentistry Thai Moogambigai Dental College and hospital,Chennai- 600107. The aim of this study is to find out the effects of non-surgical periodontal therapy on Plasma level of Reactive oxygen metabolites (ROM) and glycemic status in Type-2 diabetic patients with chronic periodontitis. one hundred and twenty patients were included in this study which was further divided into three groups. group 1 consisted of 40 patients with chronic periodontitis, group 2 consisted of 40 patients with chronic periodontitis and controlled diabetes and group 3 consisted of 40 patients with chronic periodontitis and uncontrolled diabetes. Periodontal parameters like plaque index, gingival index, bleeding on probing, pocket depth and clinical attachment levels were evaluated. Blood samples were collected to assess the fasting blood sugar (FBS), glycosylated haemoglobin (Hba1C) and Plasma reactive oxygen metabolites (ROM) levels.  All parameters were evaluated at baseline, one month and three months after non-surgical periodontal therapy. Intragroup comparison of clinical parameters showed significance at baseline, one month and three months in all the three groups. (P value<0.001) Inter group comparison of FBS and Hba1C showed significance in all the three groups. When Intragroup comparison was done for FBS and Hba1c, there was significance seen at baseline, one month and three months for FBS in all the three groups. (P value<0.001) whereas for Hba1c, there was significance observed only in group 3. Intragroup comparison of ROM showed significance at baseline, one month and three months after treatment (P value<0.001). Non-surgical periodontal treatment was effective at improving glycemic and periodontal status by reduction in the plasma ROM levels. This improvement might offer clinical benefits by decreasing the blood ROS. https://www.biotech-asia.org/vol14no1/effects-of-non-surgical-periodontal-therapy-on-plasma-level-of-reactive-oxygen-metabolites-and-glycemic-status-in-type-2-diabetic-patients-with-chronic-periodontitis/ Chronic generalised periodontitis; Hba1c; Reactive oxygen metabolites (ROM); Type 2 diabetes mellitus