eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2017-03-25 14 1 99 104 10.13005/bbra/2423 21345 article Islam H Al-Qudah 1 Ahmed Al- Radaideh 2 Nader Ahmed 3 Asok Mathew 4 General Practioner, Jordan. College of requirement Ajman University of science and technology, Al Fujairah. College of pharmacy Ajman University of science and technology, Al Fujairah. College of dentistry , Ajman University of science and technology, Al Fujairah. With advancing diagnostic capabilities and emerging technologies it is more vivid and clear that humans are under the threat of the microorganisms. Scientific fraternity is thinking deeply now how the bacterial, viral or fungal load can be addressed.It is believed that oral bacterial challenge can pose threat to multiple organ systems. The proof is highly established and double way bacterial challenge is established in the control and etiologies of diseases like low birth weight babies, coronary diseases , diabetes mellitus, Alzheimer’s  and so on. This lab study is undertaken in the microbiological lab using the specific media mitis salivarius. The study is done to the antibacterial efficacy of miswak extract in comparison with chlorhexidine, saline and distilled water. The method employed here is disc diffusion method for antibiotic sensitivity. It is noted that both chlorhexidine and miswak extract exhibited significant antibacterial property compared with saline and distilled sterile water.It is also observed that miswak extract showed better inhibition against streptococcus mutans compared with sample grown with plaque mixed population of bacterial population. The miswak extract is having comparable antibacterial efficacy with chlorhexidine. The miswak extract showed a better inhibition sensitive zone of 12mm or more when a pure colony of streptococcus mutans was applied in the mitis agar plate. https://www.biotech-asia.org/vol14no1/comparison-of-antibacterial-efficacy-of-miswak-extract-to-conventional-mouth-washes-a-microbiological-study/ Chlorhexidine  Mitis salivarius agar; Miswak;  Streptococcus mutans;