eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-09-25 13 3 1797 1803 10.13005/bbra/2332 15524 article Abbas Mohammadi 1,2 Mohammad Reza Baneshi 3 Zakaria Vahabzadeh 4 Tahereh Khalili 1 Department of Clinical Biochemistry,Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. Modeling in Health Research Center, Institute for Futures Studies in Health, Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran. Clinical biochemistry department, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. To investigate the effect of lecithin on FMO3 and FMO5 gene expression, L-α-lecithin or ethanol 30% (as control) was administrated to female N-mary mice as intraperitoneal injection and animals were sacrificed 48h after treatment. The relative expression of mRNA and protein were assessed by real-time PCR and western blotting analysis. In this study, FMO5 expression was also evaluated in HepG2 cell line. FMO3 mRNA expression in mice liver was increased to 1.8-fold in animal received lecithin compared to control group, While FMO5 expression did not showed any changes as in vivo and in vitro experiments. The our results are suggested to induce of FMO3 expression by lecithin. https://www.biotech-asia.org/vol13no3/the-influence-of-lecithin-administration-on-hepatic-expression-fmo3-and-fmo5-genes-in-n-mary-mice/ Lecithin; flavin-containing monooxyganase; gene expression