eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-06-25 13 2 1121 1132 10.13005/bbra/2141 11640 article Praveen Kumar Kusuma 1 Girijasastry Vedula 2 Medicinal Chemistry Research Lab, Vaagdevi College of Pharmacy, Kishanpura, Hanamkonda, Warangal-506001, Telangana State, India. Department of Pharmaceutical Sciences, College of Pharmacy, Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India. Heterocyclic chemistry comprise as a minimum half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of a lot of pharmaceutical, agrochemical and veterinary products. Quinazoline nucleus is a very attractive and useful scaffold in medicinal chemistry. The synthesized compounds were screened for in vitro and in-vivo antioxidant activity. The presence of antioxidants has been reported to protect lipids, blood and body fluids against the attack of reactive oxygen species like peroxide, superoxide and hydroxyl radicals. The presence of antioxidants in Test compounds (7a1, 7a2, 7a3, 7a4, 7a5, 7a6, 7a7, 7a8, 7b1, 7b2, 7b3, 7b4, 7b5, 7b6, 7b7 & 7b8) might be responsible for their observed antioxidant activity. https://www.biotech-asia.org/vol13no2/in-vitro-and-in-vivo-antioxidant-property-of-novel-2-phenyl-quinazoline-43h-one-derivatives/ Quinazoline; Peroxide; Superoxide; Antioxidant activity