eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-03-31 13 1 91 94 10.13005/bbra/2008 6654 article Amin Hooshyar Chichaklu 1,2 Manouchehr Ahmadi Hedayati 2,3 Farshad Sheykh Esmaili 3 Ebrahim Ghaderi 4 Mohammad Hossein Dareh Shiri 1,2 Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran Department of Microbiology, Kurdistan University of Medical Sciences, Sanandaj, Iran Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran Department of Statistics and Epidemiology, Kurdistan University of Medical Sciences, Sanandaj, Iran. Infection with H. pylori leads to digestive diseases including gastritis, peptic ulcer, and gastric adenocarcinoma. The virulence factors of H. pylori outer membrane proteins or Hop (Helicobacter pylori outer membrane protein) as an auto transporter and has widely adhesion properties, phase changes and recombination. H. pylori genome is widely encoded HopQ (Helicobacter pylori outer membrane protein Q), which affect the strains of H. pylori binding to human epithelial cells. The aim of this study determine the prevalence of  hopQ alleles and associated Between cagA and vacA s1 with hopQ I gene in H. pylori strains isolated from patients with peptic ulcer referred to Towhid Hospital in Sanandaj (2014). Biopsy specimens from 100 patients with peptic ulcer H. pylori positive were collected and separated, different allele hopQ, vacA, cagA by PCR (Polymerase Chain reaction) was determined. The relationship between genes, cagA and vacA s1 hopQ I with Chi-square test SPSS version 20 (version 19, SPSS Inc., Chicago, IL) was used. P value <0.05 was considered as significant. The frequency of genes hopQ I, hopQ II, cagA, vacA s1, vacA s2, respectively, 54 (54%), 46 (46%), 51 (51%), 83 (83%), 17 (17 %). The relationship between hopQ I and cagA (P<0.01), hopQ I and vacA s1 (P<0.026), respectively. In this study, the presence of the CagA and hopQ I, HopQ I and VacA S1 gene in patients with gastric ulcer statistically significant relationship was found. https://www.biotech-asia.org/vol13no1/prevalence-of-hopq-alleles-and-relationship-between-caga-and-vaca-s1-with-hopq-i-gene-in-helicobacter-pylori-strains-isolated-from-patients-with-peptic-ulcer-referred-to-towhid-hospital-in-sanandaj-2/ Helicobacter pylori; HopQ; Peptic ulcer; outer membrane proteins; Sanandaj