eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-03-31 13 1 135 145 10.13005/bbra/2016 7383 article Elaheh Gholami Parizad 1 Eskandar Gholami Parizad 2 Iraj Pakzad 3 Azar Valizadeh 3 Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran Student research committee, Ilam University of Medical Sciences, Ilam, Iran. Psychosocial Injuries Prevention Research Center, Ilam University of Medical Sciences, Ilam, Iran- Public Health Department, Ilam University of Medical Sciences, Ilam, Iran Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran. Secretion is an essential duty for prokaryotes to better interact with their surroundings or host. In particular, the production of extracellular proteins and peptides is important in many aspects of survival and organism adaptation to its ecological niche. Secretion systems in bacteria are multi component protein structures used to transport molecules across bacterial membranes. Secretion systems are usually classified into 7 groups: Type I, II, III, IV, V, VI, VI and chaperons navigating the pathways are also a part of the system. Since this systems can transport a variety of different pathogenic factors outside of the bacterial cell and establish the ability to communicate with the environment in which the bacteria live. This is important about the human pathogenic bacteria because by understanding the components and functions of these protein transport systems, we can find the right solution to deal with them. Furthermore, these systems can be used for biological fights. https://www.biotech-asia.org/vol13no1/a-review-of-secretion-systems-in-pathogenic-and-non-pathogenic-bacteria/ secretion systems; sec system; Tat system; protein traffic; transfer proteins