eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2015-12-25 12 3 2383 2386 10.13005/bbra/1914 3662 article Farzad Amuzadeh Omrani 1 Mohammad Emami 1 Mohammadmahdi Sarzaeem 1 Reza Zarei 2 Ali Yeganeh 3 Assistant Professor of Orthopedic Surgery, Imam Hossein hospital ,Shahid Beheshti University of Medical Sciences, Tehran, Iran Resident of Orthopedic Surgery, Imam Hossein hospital , Shahid Beheshti University of Medical Sciences, Tehran, Iran Associate Professor of Orthopedic Surgery, Rasoul Akram Hospital , Iran University of Medical Sciences, Tehran, Iran Post-operative total hip arthroplasty surgical wound infections are associated with substantial morbidity, mortality, and economic burden. Intra-wound vancomycin powder application may prevent infections after hip surgery. The objectives of this study is to answer the question as to whether the application of 2 gram intra-wound vancomycin powder In patients undergoing total hip arthroplasty, lead to reduced rates of postoperative surgical site infections or not? From April 2013, 125 patients had consent prior to their hip surgery. These 125 patients had total hip arthtoplasty by three different surgeons at Imam Hossein hospital. All patients received either 2 grams of IV Cefazolin one hour prior to the incision or 1 gram of IV Vancomycin one hour prior to the incision in patient with a Penicillin allergy. Near the end of the procedure, the wound was thoroughly irrigated with normal saline. for All patients befor surgical wound closure 2 gram of Vancomycin powder was poured into the wound. Postoperatively, patients continued on intravenous antibiotics for twenty-four hours. All patients underwent routine postoperative surgical care including physical therapy, routine radiographs, and routine managment of pain medications. Laboratory tests include Hb , BUN, Cr and electrolits were done before surgery and postoperatively after 48 hours and 7 days. All patients were discharged within the first 3 days after surgery and follow-up at weeks 2 and 4 and one year after surgery was performed. During the course of follow up that has ranged from one months to one year, sixteen of patients experienced surgical site infection. 10 patients were lost to follow up. No allergic reactions or adverse outcomes were reported from the use of 2 gram of Vancomycin powder prior to closure. Although intra-wound application of Vancomycin is known to minimize infections in spinal surgery little previous studies reported if Vancomycin application will reduce surgical site infection in hip surgeries. This study demonstrates that intra-wound application of Vancomycin reduces surgical site infection in total hip arthroplasty without any adverse complications. https://www.biotech-asia.org/vol12no3/the-effect-of-intra-wound-vancomycin-powder-application-in-reducing-surgical-site-infections-after-total-hip-arthroplasty/ Intra-wound Vancomycin; Total Hip Arthroplasty; Surgical Site Infection