eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2015-12-25 12 3 1947 1955 10.13005/bbra/1861 3888 article Navid Kalani 1 Leili Mosalanejad 2 Saeed Abdolahifard 3 Student Research Committee - Jahrom University of Medical Sciences - Jahrom- Iran Assistant professor - Department of Mental Health – Research center for social determinants of health - Jahrom University of Medical Sciences – Jahrom- Iran Student Research Committee. Shiraz University of Medical Sciences - Shiraz - Iran MS is a chronic, progressive disease of the central nervous system which is characterized by chronic inflammation and destruction of the nervous system neurons. Following this illness, physical disabilities and mental changes occur on which are effective on the MS patient's self-esteem and his quality of life.  This study is an experimental study before and after intervention. In this study, all patients with chronic physical and mental illness other than MS, more than years had passed since their diagnosis, were literate, and with a  non progressive form of MS were included in the group. The group sessions were held to all patients with including  criteria and at that meeting the patients completed the Perceived Stress Scale and Hope Schneider Questionnaire. Then people in 10 sessions  participated in a group hope therapy . Then they received the complementary  intervention through a mobile phone with meaning-based messages that contained sentences on hope and promoting inhibition of stress. Samples  . In the end, the post-test was performed on patients and the means were compared with each other. The results showed that the mean expectancy increased after the intervention (p =0.02). Moreover, the perceived stress levels decreased after the intervention. (P = 0. 0001) Using methods such as   hope therapy  with  mobile based learning  have a special place in this context and they increase hope and reduce stress levels in patients with multiple sclerosis. So, with effectively planning and the usual treatments, we can improve mental health and even improve the prognosis of these patients. https://www.biotech-asia.org/vol12no3/the-effect-of-hope-therapy-on-hope-and-perceived-stress-levels-in-ms-patients/ Multiple sclerosis; hope; perceived stress; hope therapy