eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2015-08-15 12 2 1659 1663 2696 article Uma Sudhakar 1 T. Ramakrishnan 2 A. Rekha 3 H. Tamizhchelvan 4 V. Shankar Ram 5 Kamal kannadasan 6 Professor and Head, Thaimoogambigai Dental college, Mugappair , Chennai -600107 Professor, VP, Meenakshi Ammal Dental college, Mugappair , Chennai -600107 PG student, Thaimoogambigai Dental college, Mugappair , Chennai -600107 Professor, Oral pathology, Sri Ramachandra Dental college , Mugappair , Chennai -600107 Reader, Thaimoogambigai Dental college, Mugappair , Chennai -600107 Professor, Oral surgery ,Thaimoogambigai Dental college. Mugappair , Chennai -600107 Chronic Periodontitis, an inflammatory disease caused by oral bacteria stimulates the host cells,neutrophils which release Reactive Oxygen Species(ROS) as a part of immune response. Excess ROS  is one of the pathological features in the periodontal lesion. Recently, Reactive Oxygen  Metabolites(ROM) were recognized as a useful measure of blood ROS .The  aim of this study is to estimate the prevalence of  ROM in Plasma, saliva and Gingival crevicular fluid in Chronic Periodontitis, chronic gingivitis and healthy controls. The study population  consisted of 45 subjects belonging to both the sexes were randomly selected . Subjects  were divided into three groups , Healthy periodontium ( HP)(Group I) and Chronic  Gingivitis (CG)(Group II), Chronic Periodontitis(CP) ( Group III). GCF, saliva  and plasma were collected in all  the three groups to estimate  the Reactive oxygen metabolite levels. ROM levels in plasma concentration were almost the same in all the groups [ pvalue 0.13]. The values obtained in saliva and GCF were significantly higher in Chronic Periodontitis group compared to Chronic Gingivitis and Healthy Periodontium.[ pvalue < 0.001]. The results  of our study suggested  that a significant oxidative stress may occur in Periodontitis. The findings also suggest that it might play an important role in the pathology of Periodontitis and the associated tissue damage. https://www.biotech-asia.org/vol12no2/prevalence-of-reactive-oxygen-metabolite-levels-in-plasma-gcf-and-saliva-in-chronic-periodontitis-chronic-gingivitis-and-healthy-periodontium-a-biochemical-study/ ROM; plasma; saliva; GCF; Chronic Periodontitis