eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2015-12-25 12 2 1767 1775 2819 article David Aregovich Petrosov 1 Vadim Alexandrovich Lomazov 1 Sergey Igorevich Matorin 2 Alina Ivanovna Dobrunova 1 Valentina Ivanovna Lomazova 2 Belgorod State Agricultural University Named After V. Gorin, Russia, 308503, Belgorod region, pos. Mayskiy, ul. Vavilova 1 Belgorod National Research University, Russia, 308015, Belgorod, ul. Pobedy, 85 The article discusses the problems of structural synthesis of large discrete systems with predefined behavior, which assumes transition of a given input signal into required reference output signal. A combined method for building the procedure of synthesis based on evolutionary methods and mathematical analysis of Petri nets has been proposed. An evolutionary procedure of structural synthesis of large discrete systems with static inter-component links has been developed. Computational experiments performed with the use of the built model give evidence to the efficiency of the proposed synthesis procedure. https://www.biotech-asia.org/vol12no2/large-discrete-systems-evolutionary-synthesis-procedure/ System analysis; structural synthesis of large discrete systems; evolutionary algorithms; genetic algorithm;Petri nets;simulation modeling