The basin of the Ili River and its tributaries within Kazakhstan is limited from the south with Trans-Ili Alatau and Kungei Alatau, from the west with north-eastern spurs of the Chu-Iliysk mountains (Aitau), from the north with the Balkash lake (delta of the Ili River) and the valley of the Karatal river, from the north-east with the Zhungar Alatau, but from the east and the south-eat with the Ketmen ridge and the Terskey Alatau. We studied pollution of the Ili River run-off from the border with the People’s Republic of China – (river station of the Dubun’ village) to the Balhash lake – river station of the Ushzharma village. For this purpose we processed data on river stations of the Dubun’ pier, 164 km higher than Kapshagai HPP (hydroelectric power station), Kapshagai, Ushzharma. Available data on pollution of the Republican State Enterprise “Kazgidromet” rivers run-off is mainly presented on copper and iron. The quality monitoring network for land surface waters include gauging stations of the National Hydrometeorological Service. The main criteria for water quality according to hydrochemical parameters are values of maximum permissible concentration (MPC) of pollutants for waters bodies of fishery, potable and household water use. The level of land surface waters pollution is estimated according to a value of the complex water pollution index (WPI), which is used to compare and identify dynamics of change in water quality.