eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2015-04-28 12 1 159 167 5115 article Mikhail Nikolaevich Dudin 1 Nikolaj Vasil’evich Lyasnikov 1 Dzhurabaeva Gulnora Kahramanovna 2 Dzhurabaev Kahraman Tursunovich 2 Konstantin Jur’evich Reshetov 3 Russian Academy of Entrepreneurship, Radio St., 14, Moscow, 105005, Russian Federation Novosibirsk State Technical University, 20, K. Marx Prospekt, Novosibirsk Oblast, Novosibirsk, 630092, Russian Federation. National Institute of Business st.Yunosti, d. 5/1, Moscow, 111395, Russian Federation. This article aims to reveal main theoretical and methodological issues related to the specificity of the strategic innovation-oriented interaction of large and small business structures of the agrarian sector. As part of the presentation of this paper, the authors have obtained the following main conclusions Secure and sustainable development of national economies and the international community as a whole is not possible without a constant evolution of the agro-industrial sector, which plays a key role in the formation of an adequate level of food security; effectiveness of development of the agrarian sector can be enhanced through the use of innovative solutions, both in terms of agricultural production, and in terms of interaction of large industrial enterprises and small entrepreneurship with each other; interaction of large industrial enterprises and small entrepreneurship of the agrarian sector is strategically-oriented solutions, aimed at meeting the interests and needs of the cooperating subjects, as well as maximizing economic and other benefits in proportion to a contribution of each partner; improving the innovative strategy of interaction of large industrial enterprises and small entrepreneurship in the agrarian sphere should include two directions: ongoing collaboration (meeting functioning needs) and strategic partnerships (meeting development needs). https://www.biotech-asia.org/vol12no1/improving-the-innovative-strategy-of-interaction-of-large-industrial-enterprises-and-small-entrepreneurship-in-the-agro-industrial-sector/ Cooperation; teamwork; strategy; small entrepreneurship; large industrial enterprises; agrarian sphere