eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2015-04-28 12 1 387 391 5707 article N. Adib 1 M. Shekarchi* 1 Food and Drug Lab Research Center, Ministry of Health, Tehran, Iran. A simple, rapid and sensitive isocratic reversed-phase high performance liquid chromatography method for the determination of carvedilol in human plasma has been developed. After extraction with methanol chromatographic analysis of carvedilol in plasma was achieved on a μ-bondapack C18 column using acetonitrile- potassium dihydrogen phosphate (30: 70v/v) mixture, pH 2, as mobile phase. The flow rate was set at 1 ml/min and the emission and excitation were 350 and 238 respectively. The lower limit of detection was 0.05 ng/ml and lower limit of quantization was 0.2ng/ml. The intra and inter-day precisions (CV %) of the quality control samples were 2.45- 7.27 and 0.52-7.92% respectively. The recovery of method was %99.48±8.5. The method was applied to a bioequivalence study in human. https://www.biotech-asia.org/vol12no1/a-new-hplc-method-for-determination-of-carvedilol-in-human-plasma-and-its-application-in-bioequivalence-studies/ Carvedilol; Human plasma; HPLC; Bioequivalence