eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-06-22 12 Spl.Edn.2 741 746 10.13005/bbra/2255 13652 article Mehrdad Mahdian 1 Mohammad Reza Fazel 1 Mojtaba Sehat 2 Mahdi Mohammadzadeh 1 Hossein Akbari 1 Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran. Department of Epidemiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Road traffic injuries (RTIs) are a major public health problem, particularly in developing countries. High quality data on the burden of this problem can help to provide the preventive strategies. The aim of this study was to determine of mortality and years of life lost (YLL) due to RTI between March 2012 and March 2013 in Kashan Region, Iran. The global burden of disease (GBD) methodology 2010 was used to compute years of life lost due to premature mortality (YLL). The results showed that a total of 101 persons [83 male (82.2%), male/female sex ratio of almost 5:1] were died during the study period. The mortality rate of RTI was 25.3 per 100,000 populations and men had a greater mortality rate. No significant differences were found between the fatality rate and different seasons of the year. The YLL during our study were 3754 years for males (18.4 per 1000), 949 years for females (4.8 per 1000) and 4703 years for both sexes (12.1 per 1000). The most YLL due to premature death in males were accounted for the age group of 30-44 yr (22.1 per 1000). It can be concluded that the RTIs’ fatality rate is high in our region and should be considered as a major public health problem, notable for authorities, policymakers and strategic planners. https://www.biotech-asia.org/vol12_nospl_edn2/years-of-life-lost-and-mortality-rate-due-to-road-traffic-injuries-in-kashan-region-iran-during-2012-2013/ Years life lost; road traffic injuries; mortality rates; Iran