eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-06-18 12 Spl.Edn.2 119 127 10.13005/bbra/2182 12818 article Elena Anatolyevna Sizova 1 Elena Vladimirovna Yausheva 2 Sergey Alexandrovich Miroshnikov 1 Svyatoslav Valerievich Lebedev 1 Galimzhan Kalihanovich Duskaev 3 Orenburg State University, Russia, 460018, Orenburg, 13 Pobedy Pr. and All-Russian Research Institute of Beef Cattle Breeding, Russia, 460000, Orenburg, 29, 9 Yanvarya St. All-Russian Research Institute of Beef Cattle Breeding, Russia, 460000, Orenburg, 29, 9 Yanvarya St. Orenburg State University, Russia, 460018, Orenburg, 13 Pobedy Pr. All-Russian Research Institute of Beef Cattle Breeding, Russia, 460000, Orenburg, 29, 9 Yanvarya St. The common practice of using iron nanoparticles in human and veterinary medicine as well as their potential use microelement-based medicines determine the need for studying the impact that nanoparticles have on the exchange of chemical elements in the body. The study involved a Wistar rats model using iron nanoparticles (nanoFe) obtained through high-temperature condensation (d = 80 ± 5 nm). The study on genetically engineered luminescent strain E. coli K12 TG1 had a pre-installed non-toxic concentration of nanoFe. Atomic emission and mass spectrometry showed the presence of 25 chemical elements in the animals’ liver after seven nanoFe intramuscular injections had been given to them. The experiment revealed no disturbance in the liver microstructure. However, an investigation into the dynamics of transaminases (alanine transaminase (ALT), aspartate transaminase (AST)) revealed an increase in their activity. On Day1 of the experiment the LDH activity went 116.3% up (p <0.001) to go down gradually within 21 days.Intramuscular nanoFe injections came along with certain alteration in the exchange of chemical elements. A single dose of iron nanoparticles caued, in the first seven days, depletion of the liver and its saturation with toxic elements. On the first day after the first injection this was manifested through an increase in the concentration of Pb by 20.0% (p <0.05), Sn by 33.3% (p <0.05), Sr by 66.67% (p <0.01). The most significant adaptive changes in the toxic elements exchange of were observed for Al and Sr. The iron content in the liver decreased on Day 7 after the first injection by 19.35% (p <0.05), Day 2 by 28.9% (p <0.05), Day 3 by 7.01%, Day 7 by 16.79% (p <0.05) compared to the controls.The pool of the macronutrients Ca, K, Mg, Na, P (the sum of the substance amount, mole) was found to vary through the experiment by 4.1–10.4%. Reduction of calcium concentration one day following the first injection (in comparison to the controls) was 6.81%; on Day 7 after the second injection – by 18.58% (p <0.05); after the third and the seventh injections – by 6.1% and 12.4% (p <0.01), respectively. Various studies suggest that there is a need for additional correction of the elemental composition in diets against iron nanoparticles injections. https://www.biotech-asia.org/vol12_nospl_edn2/element-status-in-rats-at-intramuscular-injection-of-iron-nanoparticles/ Element Status; Iron Nanoparticles; Rats