eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-06-18 12 Spl.Edn.2 65 70 10.13005/bbra/2174 12791 article Abotaleb Ghorbanzade 1 Parviz Shahabi 2 Firouz Gaderi Pakdel 3 Hadi Ebrahimi 4 Mina Sadighi 5 Behnaz Sadeghzadeh Oskouei 1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Neurophysiology Research Center, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Physiology, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran. The aim of this study was investigation of metabotropic glutamate receptors II/ III on spike-and-wave discharges in perioral somatosensory cortex of male WAG/Rij rats. Eighteen male WAG/Rij rats was used in this experiment. Rats anesthetized with a combination of ketamine and xilusinip and 2 μl of drugs injected with a 10 μl Hamilton syringe bilaterally. At the end of the experiment, all animals were killed by high dose of ketamine. The brain was removed rapidly and fixed in 10% formalin. Cresyl violet stained coronal sections were viewed with a light microscope to verify cannula placement. In all groups mean numbers and mean duration of Spike-and-wave discharges was decreased, but peak frequency was only in L-AP4 group was reduced. These agonists are able to suppress epileptic discharges in WAG/Rij rats and could be useful for treatment of Absence epilepsy in the future. https://www.biotech-asia.org/vol12_nospl_edn2/effect-of-metabotropic-glutamate-receptors-ii-iii-agonists-on-spike-wave-discharge-in-primary-somatosensory-perioral-cortex-of-male-wagrij-rats/ Metabotropic; Glutamate; WAG/Rij; Spike-and-wave; Perioral somatosensory cortex