eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-06-22 12 Spl.Edn.2 731 740 10.13005/bbra/2254 13649 article Zhanat Kadyrbekovna Zhaznayeva 1 Raikhan Rimbayevna Beisenova 1 Marat Rashitovich Khanturin 1 Gulnur Yerzhanovna Saspugayeva 2 Danagul Rimbayevna Beisenova 2 L.N. Gumilyov Eurasian National University Republic of Kazakhstan, 010008, Astana, 2 Satpayevast. S.Seifullin Kazakh Agrotechnical University Republic of Kazakhstan, 010000, 62Pobedyave Karaganda State University of the name of academician E.A. Buketov, Republic of Kazakhstan,100008, Karaganda, st.University 28 The article presents the results of studies of the effect of acute combined intoxication with phenylhydrazine and cobalt nitrate in the blood chemistry of the experimental rats, as well as correction of the drug “EPAM4.” It is found that high doses of studied toxicant cause mitochondrial damage of the heart muscle, cause hypoglycemia, disruption of protein metabolism in the muscles, changes in the liver parenchyma. It is shown that during the correction by the drug “EPAM 4” there was a restoration of AST activity, creatinine level in the muscle of the experimental animals, restoration of disturbed formations of total bilirubin in the cells of thymol test, glucose production. https://www.biotech-asia.org/vol12_nospl_edn2/changes-in-blood-biochemical-parameters-in-rats-against-the-background-of-acute-combined-intoxication-with-phenylhydrazine-and-cobalt-nitrate-and-drug-correction-by-epam4/ phenylhydrazine; heavy metals; cobalt; glucose; thymol test; creatinine; ALT - alanine aminotransferase; AST - aspartate aminotransferase; hypoglycemia