Of particular importance for assessing microsituation and its development, as well as the effectiveness of state anti-drug policy at various levels, has effective state monitoring system that would not only monitor the current status, but also by determining the level of individual indicators, criteria and indicators to determine possible changes in the strategic perspective and proactively develop and implement appropriate measures. Develop a set of indicators, criteria and indicators for the status and development of drug prevention, rehabilitation and reintegration of consumers of narcotic drugs and psychotropic substances aims at improving the efficiency and effectiveness of anti-drug policies with the increased use of information and analytical capabilities and promote functional application of the tools of this system. Its creation is based on a specialized system for the collection, processing and storage of information, analysis and forecasting of tendencies of development of the drug situation, as well as appropriate productive and timely prevention of the negative dynamics of the considered processes. To achieve this goal, the authors proposed to use the ontology-related method of forming a set of relevant indicators, criteria and indicators. The development of such a complex will provide, on the one hand, the strengthening of the coordination of the impacts of administrative structures and controls the processes of drug prevention, rehabilitation and reintegration of consumers of narcotic drugs and psychotropic substances, and on the other, will be an effective instrument of management effectiveness and sustainability of anti-drug policies at different levels.