eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2014-04-28 11 1 6402 article V. Ramya 1 Bhuvaneshwarri 1 Preethe Paddmanabhan 1 N. Manisundar 1 Department of Periodontics, Sree Balaji Dental College and Hospital, Bharath University, Chennai, India. Alzheimer’s disease is the most common form of dementia. It is a brain disorder which gradually destroys the ability to reason, remember imagine and learn. Over the course of the disease people with alziemer disease no longer recognizes themselves or much about the world around them. Periodontal infections may result in harmful pathogenic products leading to systemic inflammatory responses. Elevated systemic inflammatory response may contribute to the exacerbation of existing brain pathologies. Infections may also contribute to vascular pathology with the potential to impact brain function. https://www.biotech-asia.org/vol11no1/alziemers-disease-and-periodontal-disease-bidirectional-interrelationships/ AD- alziemer’s disease; CDR –clinical dementia rating