Chikungunya gained insight by the 2006 epidemic seen in India and Islands of the Indian Ocean and since then it has become a major disease with no commercial vaccine available. A number of epidemiological studies have been done to trace back the evolution of the Chikungunya Virus (CHIKV) and the reasons which led to the re-emergence of the epidemic & the spread of disease across borders which pose threat in the future as seen before. In this review, based on epidemiological data available several parameters of clinical importance are being analysed and a hypothetical cure is proposed based on the mechanism of action of virus and its life cycle and the use of nano-encapsulation for efficient delivery of the drug.