eng Oriental Scientific Publishing Company Biosciences Biotechnology Research Asia 0973-1245 2016-06-10 11 Spl.Edn.1 363 368 10.13005/bbra/1432 11889 article T.Yuvarani 1 V. Anuradha 2 N. Yogananth 3 M. Syed Ali 3 R. Karthik 4 Department of Biotechnology, D.G.Vaishnav College, Arumbakkam, Chennai -600106, India Department of Biochemistry, Mohamed Sathak College of Arts & Science, Sholinganallur, Chennai-600119, India Department of Biotechnology, Mohamed Sathak College of Arts & Science, Sholinganallur, Chennai-600119, Tamilnadu, India Department of Marine Biotechnology, AMET University, Kanathur, Chennai - 603112. In the Present study, Molecular modelling and structure analysis was performed for S-ribosyl homocysteinase from Aeromonas hydrophila. This is to determine new set of compounds that can be explored as antibiotics sensing and targeting the Quorum sensing proteins. The Probable ligands and their binding sites were also determined using ligprof server. HPS[2- Amino- 4- Mercapto- Butyric acid] was found to be the best ligand which can bind to the 3D structure of the target protein. https://www.biotech-asia.org/vol11_nospl_edn1/molecular-modelling-and-structure-analysis-of-s-ribosyl-homocysteinase-from-aeromonas-hydrophila/ Aeromonas hydrophila; Quorum sensing; S-ribosyl homocysteinase; AI-2 synthase; Insilico analysis