The present study was aimed to evaluate the toxic effect of both Chlorpyrifos and Profenofos (organophosphorous insecticides) each alone and in their combinations with either propolis or ginseng, the present study seeked to elucidate the possible ameliorative role of propolis and ginseng in alleviating the toxicity of both Chlorpyrifos and Profenofos when given to male rats. This was done through studying the effects of both Chlorpyrifos and profenofos on some Immunological function parameters like IgG, IgM and by measuring TNF-α level. Animals were divided into nine groups; The 1st (Control group), The 2nd (Chlorpyrifos treated group) Animals for 60 days, The 3rd (Profenofos treated group), The 4th (Propolis treated group), The 5th (Ginseng treated group), The 6th (Chlorpyrifos + Propolis treated group)A, The 7th (Chloropyrifos+Ginseng treated group), The 8th (Profenofos +Propolis treated group), The 9th (Profenofos +Ginseng treated group). Results showed that there was a correlation between CPF and PRF administration and the highly significant increase of the TNF-a, while administration of both propolis and ginseng highly ameliorate these dangerous toxicity markers and also increase the immune capacity by significant increasing of immunoglobulins.